p38 alpha MAPK polyclonal, anti-human, mouse, rat, dog

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Immune System, Signal Transduction, Signaling Molecules and Interaction, Transcription

Description:
p38 alpha MAPK (Mitogen-activated protein kinase 14; SAPK2A) is activated by environmental stressors, pro-inflammatory cytokines and lipopolysaccharide. In turn it phosphorylates various transcription factors including ELK1 and ATF2 and downstream kinases such as MAPKAPK2 and MAPKAPK5. p38 alpha MAPK is activated at the Thr-X-Tyr motif by the dual specificity kinases MAP2K3, MAP2K6 and MAP2K4. In addition it can be phosphorylated by ATM or ATR upon DNA damage. It can be inhibited by dual specificity phosphatases such as DUSP1, and its kinase activity inhibited by pyridinyl-imidazole compounds that are cytokine-suppressive anti-inflammatory drugs (CSAID).

Alternate Names: p38 MAPK, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting-protein 2, MAP kinase MXI2, SAPK2A, MAPK14

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:100-1:500

Accession No.: Q16539

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human p38 alpha MAPK.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.