P4HB polyclonal, anti-human, mouse

Background:
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Synonyms: PDI, ERBA2L, PDI, PDIA1, PO4DB

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human P4HB

Gene Symbol: P4HB

Gene ID: 64714

Swiss prot: P07237

Calculated MW: 57kDa

Recommended dilution:
WB 1:8000-12000, IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.