P53 polyclonal, anti-human

Quantity: 100 µg

Background:
The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

Description:
Rabbit IgG polyclonal antibody for Cellular tumor antigen p53 (TP53) detection. Tested with WB, IHC-P in Human.

Synonyms:
Antigen NY-CO-13 antibody, BCC7 antibody, Cellular tumor antigen p53 antibody, Cys 51 Stop antibody, FLJ92943 antibody, HGNC11998 antibody, LFS1 antibody, Mutant tumor protein 53 antibody, p53 antibody, p53 Cellular Tumor Antigen antibody, p53 tumor suppressor antibody, P53_HUMAN antibody, Phosphoprotein p53 antibody, Tp53 antibody, Transformation related protein 53 antibody, TRP53 antibody, Tumor protein p53 antibody, Tumor suppressor p53 antibody, Tumour Protein p53 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human P53 recombinant protein (Position: A74-D393). Human P53 shares 83% and 85% amino acid (aa) sequences identity with mouse and rat P53, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.