p53 polyclonal (Sumoylation Site Specific), anti-human
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In stock
SKU
AC-AP2505b
Catalog Number: AC-AP2505b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2571
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2571
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. P53 is subject to modification by conjugation of SUMO-1. A p53 mutant deficient for MDM2 binding is poorly sumoylated in vivo compared to wild-type p53. Overexpression of MDM2 increases the level of p53 sumoylation, which is further stimulated by expression of ARF. These results show that p53 sumoylation is regulated by MDM2- and ARF-mediated nucleolar targeting.
Other Names:
Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
Target/Specificity:
This p53 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from human p53.
Antigen Region:
364-393
Antigen Type: Synthetic Peptide
Gene Name: TP53
Gene ID: 7157
Primary Accession: P04637
NCBI Accession: NP_000537.3;NP_001119584.1;NP_001119585.1;NP_001119586.1;NP_001119587.1;NP_001119588.1;NP_001119589.1;NP_001119590.1;NP_001263624.1;NP_001263625.1;NP_001263626.1;NP_001263627.1;NP_001263628.1;NP_00126
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. P53 is subject to modification by conjugation of SUMO-1. A p53 mutant deficient for MDM2 binding is poorly sumoylated in vivo compared to wild-type p53. Overexpression of MDM2 increases the level of p53 sumoylation, which is further stimulated by expression of ARF. These results show that p53 sumoylation is regulated by MDM2- and ARF-mediated nucleolar targeting.
Other Names:
Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
Target/Specificity:
This p53 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from human p53.
Antigen Region:
364-393
Antigen Type: Synthetic Peptide
Gene Name: TP53
Gene ID: 7157
Primary Accession: P04637
NCBI Accession: NP_000537.3;NP_001119584.1;NP_001119585.1;NP_001119586.1;NP_001119587.1;NP_001119588.1;NP_001119589.1;NP_001119590.1;NP_001263624.1;NP_001263625.1;NP_001263626.1;NP_001263627.1;NP_001263628.1;NP_00126
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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