p53DINP1 polyclonal, anti-human, mouse, rat

Background:
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Alternative Name:
p53DINP1, TP53INP1, P53DINP1, SIP, DKFZp434M1317, FLJ22139, p53 damage inducible nuclear protein 1, p53 dependent damage inducible nuclear protein 1, p53 inducible nuclear protein 1, p53 inducible p53DINP1, p53-dependent damage-inducible nuclear protein 1, p53DINP1, SIP, Stress induced protein, Stress-induced protein, T53I1, Teap, TP53 DINP1, TP53 INP1, TP53DINP1, TP53INP1, TP53INP1A, TP53INP1B, Tumor protein p53 inducible nuclear protein 1, Tumor protein p53-inducible nuclear protein 1,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: p53DINP1 polyclonal antibody detects endogenous levels of p53DINP1 protein.

Immunogen:
Full length recombinant protein of human p53DINP1.

MW: 27 kDa

Swiss-Prot: Q96A56(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.