p57 Kip2 polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
CDKN1C(Cyclin-dependent kinase inhibitor 1C) also called p57(KIP2) or KIP2, is a protein which in humans is encoded by the CDKN1C imprinted gene. The CDKN1C gene encodes p57(KIP2), a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. The CDKN1C gene is paternally imprinted, with preferential expression of the maternal allele. Matsuoka et al.(1995) demonstrated that the CDKN1C gene is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, making it a tumor suppressor candidate. The CDKN1C gene contains 3 exons. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndromesuggesting that it is a tumor suppressor candidate. Diaz-Meyer et al.(2005) concluded that CDKN1C may be downregulated by multiple mechanisms including some that do not involve promoter methylation.

Description:
Rabbit IgG polyclonal antibody for Cyclin-dependent kinase inhibitor 1C (CDKN1C) detection. Tested with WB in Mouse, Rat.

Synonyms:
Beckwith Wiedemann syndrome antibody, BWCR antibody, BWS antibody, CDKI antibody, CDKN 1C antibody, CDKN1C antibody, CDN1C_HUMAN antibody, Cyclin dependent kinase inhibitor 1C antibody, Cyclin dependent kinase inhibitor p57 antibody, Cyclin-dependent kinase inhibitor 1C antibody, Cyclin-dependent kinase inhibitor p57 antibody, KIP 2 antibody, KIP2 antibody, p57 antibody, p57 Kip 2 antibody, p57Kip2 antibody, WBS antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of mouse p57 Kip2(51-70aa RLAELNAEDQNRWDFNFQQD), identical to the related rat sequence, and different from the related human sequence by two amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of mouse p57 Kip2(51-70aa RLAELNAEDQNRWDFNFQQD), identical to the related rat sequence, and different from the related human sequence by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.