p70 S6Kβ polyclonal, anti-human, mouse, rat

Background:
p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade. Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Alternative Name:
S6K-beta-2, S6K2, P70S6K2, p70-S6K 2, SRK, S6K-beta, p70 S6 kinase beta, p70 S6K-beta, p70 S6KB, p70-beta, 70 kDa ribosomal protein S6 kinase 2, EC 2.7.11.1, KS6B2, p70 beta, p70 ribosomal S6 kinase beta, p70 S6 kinase beta, p70 S6K-beta, p70 S6KB, p70 S6Kbeta, p70(S6K) beta, p70-beta, p70-S6K 2, P70S6K2, p70S6Kb, Ribosomal protein S6 kinase 70kDa, polypeptide 2, Ribosomal protein S6 kinase beta 2, Ribosomal protein S6 kinase beta-2, Rps6kb2, S6 kinase related kinase, S6 kinase-related kinase, S6K beta 2, S6K beta, S6K-beta, S6K-beta-2, S6K2, Serine/threonine protein kinase 14 beta, Serine/threonine-protein kinase 14B, SRK, STK14B,

Application Dilution:
WB:1:500
ICC:1:200
IHC:1:200
FC:1:100-1:200

Specificity: p70 S6Kβ polyclonal antibody detects endogenous levels of p70 S6Kβ protein.

Immunogen:
peptide

MW: 70 kDa

Swiss-Prot: Q9UBS0

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.