p73 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
p73, also known as tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation.

Description:
Rabbit IgG polyclonal antibody for Tumor protein p73 (TP73) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
p53 like transcription factor antibody, p53 Related Protein antibody, p53 Related Protein antibody, p53-like transcription factor antibody, p53-related protein antibody, p73 antibody, P73_HUMAN antibody, TP 73 antibody, TP73 antibody, TP73 antibody, Tumor Protein p73 antibody, Tumor Protein p73 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human p73 recombinant protein (Position: M1-E198). Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.