PABPC4 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP17240c
Catalog Number: AC-AP17240c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37035
Applications: WB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37035
Applications: WB
Datasheet
Request Information
Background:
Poly(A)-binding proteins (PABPs) bind to the poly(A) tailpresent at the 3-prime ends of most eukaryotic mRNAs. PABPC4 orIPABP (inducible PABP) was isolated as an activation-induced T-cellmRNA encoding a protein. Activation of T cells increased PABPC4mRNA levels in T cells approximately 5-fold. PABPC4 contains 4RNA-binding domains and proline-rich C terminus. PABPC4 islocalized primarily to the cytoplasm. It is suggested that PABPC4might be necessary for regulation of stability of labile mRNAspecies in activated T cells. PABPC4 was also identified as anantigen, APP1 (activated-platelet protein-1), expressed onthrombin-activated rabbit platelets. PABPC4 may also be involved inthe regulation of protein translation in platelets andmegakaryocytes or may participate in the binding or stabilizationof polyadenylates in platelet dense granules. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
Other Names:
Polyadenylate-binding protein 4, PABP-4, Poly(A)-binding protein 4, Activated-platelet protein 1, APP-1, Inducible poly(A)-binding protein, iPABP, PABPC4, APP1, PABP4
Target/Specificity:
This PABPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human PABPC4.
Antigen Region:
219-247
Antigen Type: Synthetic Peptide
Gene Name: PABPC4
Gene ID: 8761
Primary Accession: Q13310
NCBI Accession: NP_001129125.1;NP_001129126.1;NP_003810.1
Other Accession: NP_003810.1;NP_001129126.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Poly(A)-binding proteins (PABPs) bind to the poly(A) tailpresent at the 3-prime ends of most eukaryotic mRNAs. PABPC4 orIPABP (inducible PABP) was isolated as an activation-induced T-cellmRNA encoding a protein. Activation of T cells increased PABPC4mRNA levels in T cells approximately 5-fold. PABPC4 contains 4RNA-binding domains and proline-rich C terminus. PABPC4 islocalized primarily to the cytoplasm. It is suggested that PABPC4might be necessary for regulation of stability of labile mRNAspecies in activated T cells. PABPC4 was also identified as anantigen, APP1 (activated-platelet protein-1), expressed onthrombin-activated rabbit platelets. PABPC4 may also be involved inthe regulation of protein translation in platelets andmegakaryocytes or may participate in the binding or stabilizationof polyadenylates in platelet dense granules. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
Other Names:
Polyadenylate-binding protein 4, PABP-4, Poly(A)-binding protein 4, Activated-platelet protein 1, APP-1, Inducible poly(A)-binding protein, iPABP, PABPC4, APP1, PABP4
Target/Specificity:
This PABPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human PABPC4.
Antigen Region:
219-247
Antigen Type: Synthetic Peptide
Gene Name: PABPC4
Gene ID: 8761
Primary Accession: Q13310
NCBI Accession: NP_001129125.1;NP_001129126.1;NP_003810.1
Other Accession: NP_003810.1;NP_001129126.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review