IPMK polyclonal, anti-human, mouse, rat, primate
€470.00
In stock
SKU
AC-AP70567
Background:
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12027805, PubMed:12223481). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610).
Other Names:
IPMK; IMPK; Inositol polyphosphate multikinase; Inositol 1; 3,4,6-tetrakisphosphate 5-kinase
Antigen Type: synthetic peptide
Antigen Type: IPMK
Gene ID: 253430
Primary Accession: Q8NFU5
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12027805, PubMed:12223481). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610).
Other Names:
IPMK; IMPK; Inositol polyphosphate multikinase; Inositol 1; 3,4,6-tetrakisphosphate 5-kinase
Antigen Type: synthetic peptide
Antigen Type: IPMK
Gene ID: 253430
Primary Accession: Q8NFU5
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