PABPN1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP16835b
Background:
This gene encodes an abundant nuclear protein that bindswith high affinity to nascent poly(A) tails. The protein isrequired for progressive and efficient polymerization of poly(A)tails on the 3' ends of eukaryotic genes and controls the size ofthe poly(A) tail to about 250 nt. At steady-state, this protein islocalized in the nucleus whereas a different poly(A) bindingprotein is localized in the cytoplasm. An expansion of thetrinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end ofthe coding region of this gene leads to autosomal dominantoculopharyngeal muscular dystrophy (OPMD) disease. Multiple splicevariants have been described but their full-length nature is notknown. One splice variant includes introns 1 and 6 but no proteinis formed.
Other Names:
Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2
Gene Name: PABPN1 (HGNC:8565)
Gene ID: 8106
Primary Accession: Q86U42
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes an abundant nuclear protein that bindswith high affinity to nascent poly(A) tails. The protein isrequired for progressive and efficient polymerization of poly(A)tails on the 3' ends of eukaryotic genes and controls the size ofthe poly(A) tail to about 250 nt. At steady-state, this protein islocalized in the nucleus whereas a different poly(A) bindingprotein is localized in the cytoplasm. An expansion of thetrinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end ofthe coding region of this gene leads to autosomal dominantoculopharyngeal muscular dystrophy (OPMD) disease. Multiple splicevariants have been described but their full-length nature is notknown. One splice variant includes introns 1 and 6 but no proteinis formed.
Other Names:
Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2
Gene Name: PABPN1 (HGNC:8565)
Gene ID: 8106
Primary Accession: Q86U42
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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