PABPN1 polyclonal (C-term), anti-human

Background:
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.

Other Names:
Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2

Target/Specificity:
This PABPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.

Antigen Region:
270-298

Antigen Type: Synthetic Peptide

Gene Name: PABPN1 (HGNC:8565)
Gene ID: 8106
Primary Accession: Q86U42
NCBI Accession: NP_004634.1
Other Accession: Q28165; NP_004634.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.