PACAP-related Peptide polyclonal, anti-human, rat

Quantity: 100 µl

Background:
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants.

Synonyms:
PACAP, ADCYAP1

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic rat PRP, conjugated to BSA

Form: Serum containing 0.1% sodium azide

Specificity:
Absorption with 10-100 ?g immunogen per ml diluted antiserum abolishes staining, while PRP, VIP, PHI, CRF, oxytocin and vasopressin do not. Some cross-reactivity with PACAP-27.

Reactivity: human, rat

Applications: Immunohistochemistry, suitable for frozen sections

Working DIlution: 1:20 to 1:40 immunofluorescence microscopy

Positive Control:
Stefanini-fixed frozen sections of rat duodenum, fundus or antrum

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Hannibal, J. et al. (1995) Regulatory Peptides 55: 133-148