PACRG polyclonal (N-term), anti-human

Background:
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

Other Names:
Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP

Target/Specificity:
This PACRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human PACRG.

Antigen Region:
46-74

Antigen Type: Synthetic Peptide

Gene Name: PACRG
Gene ID: 135138
Primary Accession: Q96M98
NCBI Accession: NP_001073847.1;NP_001073848.1;NP_689623.2
Other Accession: NP_001073847.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.