PAK-1 polyclonal, anti-human
€422.00
In stock
SKU
251926
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Signaling Molecules and Interaction, Cell Motility, Cell Communication, Immune System, Development and Behavior, Cancers, Infectious Diseases
Description:
Serine/threonine-protein kinase PAK-1 (PAK-1) is a protein kinase that acts on a variety of targets. PAK-1 is the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK-1 is activated by CDC42 and RAC1, and is involved in dissolution of stress fibers and reorganization of focal complexes. PAK-1 is involved in regulation of microtubule biogenesis through phosphorylation of TBCB. PAK-1 activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Alternate Names: Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK, PAK1
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:500
Accession No.: Q13153
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PAK-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Cell Motility, Cell Communication, Immune System, Development and Behavior, Cancers, Infectious Diseases
Description:
Serine/threonine-protein kinase PAK-1 (PAK-1) is a protein kinase that acts on a variety of targets. PAK-1 is the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK-1 is activated by CDC42 and RAC1, and is involved in dissolution of stress fibers and reorganization of focal complexes. PAK-1 is involved in regulation of microtubule biogenesis through phosphorylation of TBCB. PAK-1 activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Alternate Names: Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK, PAK1
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:500
Accession No.: Q13153
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PAK-1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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