PAK-4 polyclonal, anti-human, mouse, rat, bovine, dog, chicken

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Signal Transduction, Cell Communication, Cell Motility, Immune System, Development and Behavior, Cancers

Description:
Serine/threonine-protein kinase PAK 4 (PAK4) activates the JNK pathway. PAK4 plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. PAK4 phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin.

Alternate Names: Serine/threonine-protein kinase PAK4, p21-activated kinase 4, PAK-4, PAK4, KIAA1142

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: O96013

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PAK4.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.