PAK1 polyclonal (T423), anti-human
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In stock
SKU
AC-AP7926d
Catalog Number: AC-AP7926d
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11382
Applications: WB, IHC-P, IF
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11382
Applications: WB, IHC-P, IF
Datasheet
Request Information
Background:
PAK1, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphorylated when activated by CDC42/p21. Structurally, the PAK1 contains 1 CRIB domain.
Other Names:
Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK1
Target/Specificity:
This PAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from human PAK1.
Antigen Region:
401-430
Antigen Type: Synthetic Peptide
Gene Name: PAK1 {ECO:0000303|PubMed:8805275, ECO:0000312|HGNC:HGNC:8590}
Gene ID: 5058
Primary Accession: Q13153
NCBI Accession: NP_001122092.1;NP_002567.3
Other Accession: Q8AXB4; Q62829; Q61036; O75914; Q64303; Q29502; Q8CIN4; Q13177; P35465; O88643; Q08E52
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
PAK1, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphorylated when activated by CDC42/p21. Structurally, the PAK1 contains 1 CRIB domain.
Other Names:
Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK1
Target/Specificity:
This PAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from human PAK1.
Antigen Region:
401-430
Antigen Type: Synthetic Peptide
Gene Name: PAK1 {ECO:0000303|PubMed:8805275, ECO:0000312|HGNC:HGNC:8590}
Gene ID: 5058
Primary Accession: Q13153
NCBI Accession: NP_001122092.1;NP_002567.3
Other Accession: Q8AXB4; Q62829; Q61036; O75914; Q64303; Q29502; Q8CIN4; Q13177; P35465; O88643; Q08E52
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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