PAK3 antibody (clone 3A12), anti-human, mouse
€435.00
In stock
SKU
AC-AT3175a
Catalog Number: AC-AT3175a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IFhttps://www.abcepta.com/products/pdf_download/AT3175a-PAK3-Antibody-monoclonal-M08">Request Information AC-AT3175a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IFhttps://www.abcepta.com/products/pdf_download/AT3175a-PAK3-Antibody-monoclonal-M08">Request Information AC-AT3175a">Request Information
Background:
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
Antigen Type:
Recombinant Protein
Gene Name: PAK3
Gene ID: 5063
NCBI Accession: NP_001121638.1;NP_001121639.1;NP_001121640.1;NP_001121644.1;NP_001121645.1;NP_002569.1
Primary Accession: O75914
Other Accession: NM_002578
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
Antigen Type:
Recombinant Protein
Gene Name: PAK3
Gene ID: 5063
NCBI Accession: NP_001121638.1;NP_001121639.1;NP_001121640.1;NP_001121644.1;NP_001121645.1;NP_002569.1
Primary Accession: O75914
Other Accession: NM_002578
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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