PAK3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

Description:
Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase PAK 3 (PAK3) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Beta PAK antibody, bPAK antibody, CDKN1A antibody, hPAK3 antibody, Mental retardation X linked 30 antibody, MRX30 antibody, MRX47 antibody, Oligophrenin 3 antibody, OPHN3 antibody, p21 (CDKN1A) activated kinase 3 antibody, p21 activated kinase 3 antibody, p21 CDKN1A activated kinase 3 antibody, P21 protein (Cdc42/Rac) activated kinase 3 antibody, PAK-3 antibody, PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 antibody, PAK3beta antibody, Pak65alpha antibody, Pak65beta antibody, Serine threonine protein kinase PAK 3 antibody, Stk4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human PAK3 (13-49aa APPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLR), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the N-terminus of human PAK3 (13-49aa APPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLR), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat.
Predicted to work with: human.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.