PAK6 polyclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO11038
Catalog Number: AC-ABO11038
Size: 100 µg
Isotype: Rabbit IgG
Applications: WB, IHC-P
Datasheet
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Size: 100 µg
Isotype: Rabbit IgG
Applications: WB, IHC-P
Datasheet
Request Information
Description: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase PAK 6(PAK6) detection. Tested with WB, IHC-P in Human;Rat;Mouse.Protein Name: Serine/threonine-protein kinase PAK 6
Protein Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. .
Other Names: Serine/threonine-protein kinase PAK 6, 2.7.11.1, PAK-5, p21-activated kinase 6, PAK-6, PAK6, PAK5
Subcellular Localization: Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction.
Tissue Specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. .
Gene ID: 106821730;56924
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PAK6(16-32aa QNFQHRVHTSFDPKEGK), identical to the related rat and mouse sequences.
Calculated MW: 74869
Purification: Immunogen affinity purified.
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Concentration (mg/ml): Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. .
Other Names: Serine/threonine-protein kinase PAK 6, 2.7.11.1, PAK-5, p21-activated kinase 6, PAK-6, PAK6, PAK5
Subcellular Localization: Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction.
Tissue Specificity: Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. .
Gene ID: 106821730;56924
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PAK6(16-32aa QNFQHRVHTSFDPKEGK), identical to the related rat and mouse sequences.
Calculated MW: 74869
Purification: Immunogen affinity purified.
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Concentration (mg/ml): Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
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