Pan-Cadherin (clone PC-79), anti-human, mouse, rat, rabbit, chicken
€445.00
In stock
SKU
251786
Catalog Nr.: 251786
Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC
Datasheet
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Size: 0.1 mg
Isotype: Mouse IgG1
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: Cell Adhesion Molecules, CAM Ligands, Cellular Antigens
Pathway and Disease: Signaling Molecules and Interaction
Description:
Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins.
Alternate Names: Pan-Cadherin, Cadherin, CDH, Cadherin-2, DH2, Neural cadherin, N-cadherin
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P10288
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Pranjal Sarma et al. 2015. Centre for Chemical Biology; CSIR-Indian Institute of Chemical Technology. Oct. 16(10): 1486–1501. PMID: 26192233.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins.
Alternate Names: Pan-Cadherin, Cadherin, CDH, Cadherin-2, DH2, Neural cadherin, N-cadherin
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Accession No.: P10288
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Pranjal Sarma et al. 2015. Centre for Chemical Biology; CSIR-Indian Institute of Chemical Technology. Oct. 16(10): 1486–1501. PMID: 26192233.
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