PANX1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8352
Background:
Gap junctions are formed by a hexameric group of proteins called connexins for the transport of low molecular weight proteins from cell to cell. Connexins, which are present in all metazoan organisms, serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and gap junction communication. The pannexin gene family encodes a second class of putative gap junction proteins. Pannexins are highly conserved in invertebrates and mammals, indicating the importance of their gap junctional coupling function. Mammalian Pannexin-1 and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. Pannexin-1 is a transmembrane protein that forms calcium-permeable gap junctions between adjacent cells and in the endoplasmic reticulum. In erythrocytes, Pannexin-1 forms a mechanosensitive ATP-permeable channel in the nonjunctional plasma membrane.
Alternative Name:
Pannexin-1, PANX1, MRS1, UNQ2529, PRO6028
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: PANX1 polyclonal antibody detects endogenous levels of PANX1 protein.
Immunogen:
Recombinant full length Human PANX1.
MW: ~ 48 kDa
Swis Prot.: Q96RD7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Gap junctions are formed by a hexameric group of proteins called connexins for the transport of low molecular weight proteins from cell to cell. Connexins, which are present in all metazoan organisms, serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and gap junction communication. The pannexin gene family encodes a second class of putative gap junction proteins. Pannexins are highly conserved in invertebrates and mammals, indicating the importance of their gap junctional coupling function. Mammalian Pannexin-1 and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. Pannexin-1 is a transmembrane protein that forms calcium-permeable gap junctions between adjacent cells and in the endoplasmic reticulum. In erythrocytes, Pannexin-1 forms a mechanosensitive ATP-permeable channel in the nonjunctional plasma membrane.
Alternative Name:
Pannexin-1, PANX1, MRS1, UNQ2529, PRO6028
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: PANX1 polyclonal antibody detects endogenous levels of PANX1 protein.
Immunogen:
Recombinant full length Human PANX1.
MW: ~ 48 kDa
Swis Prot.: Q96RD7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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