PAPP-A (clone 1_24), anti-human
€829.00
In stock
SKU
250220
Protein Family: Peptidases
Pathway and Disease: Development and Behavior
Description:
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21). This antibody is specific for native human PAPP-A. Heat and SDS-denatured PAPP-A is also recognized, but not acid treated PAPP-A .
Alternate Names: Pregnancy-associated plasma protein A, Pappalysin-1(precursor), Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGF-dependent IGFBP-4 protease, IGFBP-4ase
Application Notes: In sandwich ELISA, Product Cat. No. 250257 is used as the capture antibody and biotinylated Product Cat. No. 250220 as detection antibody. Product Cat. No. 250220 only detects unreduced PAPP-A in Western Blotting. Product Cat. No. 250220 gives the strongest signal in IHC compared to Product Cat. No. 250219 and Product Cat. No. 250257. E: 1:8,000; WB: 1:1,000; IHC: 1:200
Accession No.: Q13219
Antigen: Purified human PAPP-A
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Development and Behavior
Description:
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21). This antibody is specific for native human PAPP-A. Heat and SDS-denatured PAPP-A is also recognized, but not acid treated PAPP-A .
Alternate Names: Pregnancy-associated plasma protein A, Pappalysin-1(precursor), Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGF-dependent IGFBP-4 protease, IGFBP-4ase
Application Notes: In sandwich ELISA, Product Cat. No. 250257 is used as the capture antibody and biotinylated Product Cat. No. 250220 as detection antibody. Product Cat. No. 250220 only detects unreduced PAPP-A in Western Blotting. Product Cat. No. 250220 gives the strongest signal in IHC compared to Product Cat. No. 250219 and Product Cat. No. 250257. E: 1:8,000; WB: 1:1,000; IHC: 1:200
Accession No.: Q13219
Antigen: Purified human PAPP-A
Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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