PAPP A polyclonal, anti-human

Quantity: 100 µg

Background:
Pappalysin-1, also known as DIPLA1, is a protein that in humans is encoded by the PAPPA gene. It is mapped to 9q33.1. PAPPA is found in the ovarian follicles, follicular fluid, luteal cells, and fallopian tubes of nonpregnant women and in the seminal vesicles and seminal fluid of males. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. It has been found that circulating PAPPA is a disulfide-bridged complex with proMBP in which the subunits of the constituents are present in a 1:1 molar ratio.

Description:
Rabbit IgG polyclonal antibody for Pappalysin-1 (PAPPA) detection. Tested with WB, IHC-P in Human.

Synonyms:
ASBABP2 antibody, Aspecific BCL2 ARE binding protein 2 antibody, Differentially placenta 1 expressed protein antibody, DIPLA1 antibody, IGF dependent IGFBP 4 protease antibody, IGF-dependent IGFBP-4 protease antibody, IGFBP 4ase antibody, IGFBP-4ase antibody, IGFBP4ase antibody, Insulin like growth factor dependent IGF binding protein 4 protease antibody, Insulin-like growth factor-dependent IGF-binding protein 4 protease antibody, PAPA antibody, PAPP A antibody, PAPP-A antibody, PAPP1_HUMAN antibody, PAPPA antibody, PAPPA1 antibody, Pappalysin 1 precursor antibody, Pappalysin-1 antibody, Pregnancy Associated Plasma Protein A antibody, Pregnancy associated plasma protein A pappalysin 1 antibody, Pregnancy-associated plasma protein A antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PAPP A recombinant protein (Position: R95-Q388). Human PAPP A shares 88% amino acid (aa) sequence identity with mouse PAPP A.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.