PAR-1 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels, Transporters

Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Immune System, Cell Motility

Description:
Proteinase-activated receptor 1 (PAR-1) is a high affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. PAR-1 plays a role in platelet activation and in vascular development. A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Alternate Names: PAR-1, Protease-activated receptor 1, Proteinase-activated receptor 1, Thrombin receptor, Coagulation factor II receptor, F2R, CF2R, PAR1, TR

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P25116

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PAR-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Palygin O et al. 2016. Am J Physiol Renal Physiol. Dec 1
311(6):F1140-44. PMID#27733370
[2] Jeffers A et al. 2014. Am J Respir Cell Mol Biol. PMID#25303460.