PAR-2 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels, GTP-binding Proteins

Pathway and Disease: Signal Transduction

Description:
Proteinase-activated receptor 2 (PAR-2) is a receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. PAR-2 plays a role in the regulation of vascular tone, and is widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon.

Alternate Names: PAR-2, Proteinase-activated receptor 2, Thrombin receptor-like 1, Coagulation factor II receptor-like 1, G-protein coupled receptor 11, F2RL1, GPR11, PAR2 

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P55085

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PAR-2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Palygin O et al. 2016. Am J Physiol Renal Physiol. Dec 1
311(6):F1140-44. PMID#27733370
[2] Yau MK et al. 2013. J Med Chem. doi: 10.1021.jm400638v. PMID# 23895492.