Park6(PINK1) polyclonal(C-term), anti-human, mouse
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In stock
SKU
AC-AP6406D
Catalog Number: AC-AP6406D
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB6517
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB6517
Applications: WB
Datasheet
Request Information
Background:
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
Other Names:
Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1
Target/Specificity:
This Park6(PINK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-526 amino acids from the C-terminal region of human Park6(PINK1).
Antigen Region:
493-526
Antigen Type: Synthetic Peptide
Gene Name: PINK1
Gene ID: 65018
Primary Accession: Q9BXM7
NCBI Accession: NP_115785.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
Other Names:
Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1
Target/Specificity:
This Park6(PINK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-526 amino acids from the C-terminal region of human Park6(PINK1).
Antigen Region:
493-526
Antigen Type: Synthetic Peptide
Gene Name: PINK1
Gene ID: 65018
Primary Accession: Q9BXM7
NCBI Accession: NP_115785.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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