PARK7/DJ1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.

Description:
Rabbit IgG polyclonal antibody for Protein DJ-1 (PARK7) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
CAP1 antibody, DJ 1 antibody, DJ-1 antibody, DJ1 antibody, DJ1 protein antibody, FLJ27376 antibody, FLJ34360 antibody, FLJ92274 antibody, Oncogene DJ1 antibody, OTTHUMP00000001348 antibody, OTTHUMP00000001349 antibody, OTTHUMP00000001350 antibody, OTTHUMP00000001351 antibody, Park 7 antibody, Park7 antibody, PARK7_HUMAN antibody, Parkinson disease (autosomal recessive early onset) 7 antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, Parkinson disease protein 7 antibody, Parkinson protein 7 antibody, Protein DJ 1 antibody, Protein DJ-1 antibody, RNA binding protein regulatory subunit antibody, RS antibody, SP22 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PARK7 recombinant protein (Position: A2-D189). Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse and rat PARK7.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.