PARK7/DJ1 polyclonal, anti-human, mouse, rat

Background:
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.

Alternative Name:
DJ-1, PARK7, CAP1, DJ-1, DJ1, DJ1 protein, Epididymis secretory sperm binding protein Li 67p, FLJ27376, FLJ34360, FLJ92274, HEL S 67p, Oncogene DJ1, OTTHUMP00000001348, OTTHUMP00000001349, OTTHUMP00000001350, OTTHUMP00000001351, PARK7, PARK7, Parkinson disease (autosomal recessive, early onset) 7, Parkinson disease protein 7, Parkinson protein 7, Protein DJ-1, SP22,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:100-1:500
IHC:1:100-1:500
FC:1:50-1:100

Specificity: PARK7/DJ1 polyclonal antibody detects endogenous levels of PARK7/DJ1 protein.

Immunogen:
recombinant protein

MW: 20 kDa

Swiss-Prot: Q99497(Human) Q99LX0(Mouse) O88767(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.