PARK8 (LRRK2) polyclonal (L899), anti-human
€0.00
In stock
SKU
AC-AP7099g
Catalog Number: AC-AP7099g
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB7199
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB7199
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
Other Names:
Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Target/Specificity:
This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 931-962 amino acids from human PARK8(LRRK2).
Antigen Region:
931-962
Antigen Type: Synthetic Peptide
Gene Name: LRRK2
Gene ID: 120892
Primary Accession: Q5S007
NCBI Accession: NP_940980.3
Other Accession: NP_940980
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
Other Names:
Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Target/Specificity:
This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 931-962 amino acids from human PARK8(LRRK2).
Antigen Region:
931-962
Antigen Type: Synthetic Peptide
Gene Name: LRRK2
Gene ID: 120892
Primary Accession: Q5S007
NCBI Accession: NP_940980.3
Other Accession: NP_940980
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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