PARN polyclonal, anti-human

Background:
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: DAN, DKCB6, PFBMFT4

Cellular Location: Cytoplasm Nucleus nucleolus

Immunogen:
Recombinant protein of human PARN

Gene Symbol: PARN

Gene ID: 5073

Swiss prot: O95453

Calculated MW: 73kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.