PARN Polyclonal Antibody

Background:
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
PARN, DAN, DKCB6, PFBMFT4

Immunogen: Recombinant fusion protein of human PARN (NP_002573.1).

Swissprot: O95453
Gene ID: 5073

Calculated MW: 52 kDa/66 kDa/67 kDa/73 kDa
Observed MW: 73 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.