PARP-4 rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008],catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 VWFA domain.,subcellular location:Also found in the nucleus, associated with mitotic spindles.,subunit:Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1.,tissue specificity:Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.,

Synonyms: PARP4, ADPRTL1, KIAA0177, PARPL, Poly [ADP-ribose] polymerase 4, PARP-4, 193 kDa vault protein, ADP-ribosyltransferase diphtheria toxin-like 4, ARTD4, PARP-related/IalphaI-related H5/proline-rich, PH5P, Vault poly(ADP-ribose) polymerase, VP

Gene Name: PARP4

Gene ID: 143

SwissProt ID: Q9UKK3

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.