PARP (Cleaved) polyclonal, anti-human antibody
€395.00
In stock
SKU
AC-ABV11501-100
Catalog Number: AC-ABV11501-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Background:
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
Other Names:
PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Primary Accession: P09874
Other Accession: NP_001609
Gene Name: PARP1 (HGNC:270)
Gene ID: 142
Concentration (mg/ml): 0.2 mg/ml
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
Other Names:
PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Primary Accession: P09874
Other Accession: NP_001609
Gene Name: PARP1 (HGNC:270)
Gene ID: 142
Concentration (mg/ml): 0.2 mg/ml
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