PARP (clone 10H), anti-all species antibody
€325.00
In stock
SKU
AC-ABV10000-100
Catalog Number: AC-ABV10000-100
Size: 100 µg
Isotype: Mouse IgG
Applications: WB, ICC, E, IP
Datasheet
Request Information
Size: 100 µg
Isotype: Mouse IgG
Applications: WB, ICC, E, IP
Datasheet
Request Information
Background:
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
Other Names:
PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Primary Accession: P09874
Other Accession: NP_001609
Gene Name: PARP1 (HGNC:270)
Gene ID: 142
Concentration (mg/ml): 1.0 mg/ml
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
Other Names:
PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Primary Accession: P09874
Other Accession: NP_001609
Gene Name: PARP1 (HGNC:270)
Gene ID: 142
Concentration (mg/ml): 1.0 mg/ml
| Is Featured? | No |
|---|
Write Your Own Review