PARP (clone 7A10), anti-human antibody
€355.00
In stock
SKU
AC-ABV10016-100
Catalog Number: AC-ABV10016-100
Size: 100 µl
Host: Mouse IgG
Applications: WB, FC, ICC
Datasheet
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Size: 100 µl
Host: Mouse IgG
Applications: WB, FC, ICC
Datasheet
Request Information
Background:
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability, cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
Other Names:
PARP, PPOL, ADPRT, ADPRT1, PARP-1, pADPRT-1, PARP1
Primary Accession: P09874
Other Accession: NP_001609
Gene Name: PARP1 (HGNC:270)
Gene ID: 142
Concentration (mg/ml): 1 mg/ml
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability, cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
Other Names:
PARP, PPOL, ADPRT, ADPRT1, PARP-1, pADPRT-1, PARP1
Primary Accession: P09874
Other Accession: NP_001609
Gene Name: PARP1 (HGNC:270)
Gene ID: 142
Concentration (mg/ml): 1 mg/ml
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