PARP polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Poly [ADP-ribose] polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Description:
Rabbit IgG polyclonal antibody for Poly [ADP-ribose] polymerase 1 (PARP1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody, ADP ribosyltransferase diphtheria toxin like 1 antibody, ADP ribosyltransferase NAD(+) antibody, ADP ribosyltransferase NAD+ antibody, ADPRT 1 antibody, ADPRT antibody, ADPRT1 antibody, ARTD1 antibody, msPARP antibody, NAD(+) ADP ribosyltransferase 1 antibody, NAD(+) ADP-ribosyltransferase 1 antibody, pADPRT 1 antibody, pADPRT1 antibody, PARP 1 antibody, PARP antibody, PARP-1 antibody, PARP1 antibody, PARP1_HUMAN antibody, Poly (ADP ribose) polymerase 1 antibody, poly (ADP ribose) polymerase family, member 1 antibody, Poly [ADP-ribose]polymerase 1 antibody, Poly adenosine diphosphate ADP ribose polymerase antibody, Poly ADP ribose polymerase 1 antibody, Poly ADP ribose polymerase family member 1 antibody, Poly ADP ribose synthetase 1 antibody, Poly(ADP ribose) polymerase antibody, poly(ADP ribose) synthetase antibody, poly(ADP ribosyl)transferase antibody, Poly[ADP ribose] synthetase 1 antibody, Poly[ADP-ribose] synthase 1 antibody, PPOL antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PARP recombinant protein (Position: Q670-R858). Human PARP shares 94% and 95% amino acid (aa) sequence identity with mouse and rat PARP, respectively.E.coli-derived human PARP recombinant protein (Position: Q670-R858). Human PARP shares 94% and 95% amino acid (aa) sequence identity with mouse and rat PARP, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.