PARP11 middle region polyclonal, anti-human, mouse, rat, rabbit, pig, dog, guinea pig, horse, bovine

Background:
This is a rabbit polyclonal antibody against PARP11. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein.

Other Names:
Poly [ADP-ribose] polymerase 11, PARP-11, ADP-ribosyltransferase diphtheria toxin-like 11, ARTD11, PARP11, C12orf6

Target/Specificity:
PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.

Immunogen:
The immunogen for anti-PARP11 antibody: synthetic peptide directed towards the middle region of human PARP11

Gene Name:
PARP11 {ECO:0000303|PubMed:20106667, ECO:0000312|HGNC:HGNC:1186}
Gene Name:
57097
Swissprot ID: Q9NR21
NCBI Accession:
NP_065100
Primary Accession: Q9NR21
Other Accession: Q9NR21;NP_065100;NM_020367
Purification: Affinity Purified
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.