PARP3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61101
Background:
Poly(ADP-ribose) polymerase-3 (PARP-3) is part of the base excision repair (BER) pathway, catalyzing the poly(ADP-ribosyl)ation of nuclear proteins. Poly(ADP-ribosyl)ation, a post-translational modification following DNA damage, appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-3 is a nuclear, DNA-binding protein, which interacts with PARP-1. PARP-3 is present in actively dividing tissues with highest levels in the kidney, skeletal muscle, liver, heart and spleen. Human PARP-3 maps to chromosome 3p21-3-p21.1, a gene region that undergoes alteration in solid malignant tumors.
Alternative Name:
Poly [ADP-ribose] polymerase 3 (EC:2.4.2.30), PARP-3, hPARP-3, ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] synthase 3, pADPRT-3, PARP3, ADPRT3, ADPRTL3
Application Dilution: WB: 1:500~1:1000
Specificity: PARP3 polyclonal antibody detects endogenous levels of PARP3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PARP3.
MW: ~ 60 kDa
Swis Prot.: Q9Y6F1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Poly(ADP-ribose) polymerase-3 (PARP-3) is part of the base excision repair (BER) pathway, catalyzing the poly(ADP-ribosyl)ation of nuclear proteins. Poly(ADP-ribosyl)ation, a post-translational modification following DNA damage, appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-3 is a nuclear, DNA-binding protein, which interacts with PARP-1. PARP-3 is present in actively dividing tissues with highest levels in the kidney, skeletal muscle, liver, heart and spleen. Human PARP-3 maps to chromosome 3p21-3-p21.1, a gene region that undergoes alteration in solid malignant tumors.
Alternative Name:
Poly [ADP-ribose] polymerase 3 (EC:2.4.2.30), PARP-3, hPARP-3, ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] synthase 3, pADPRT-3, PARP3, ADPRT3, ADPRTL3
Application Dilution: WB: 1:500~1:1000
Specificity: PARP3 polyclonal antibody detects endogenous levels of PARP3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PARP3.
MW: ~ 60 kDa
Swis Prot.: Q9Y6F1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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