Patched/PTCH1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
PTCH1 is also known as PTC, BCNS or HPE7. This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Description:
Rabbit IgG polyclonal antibody for Protein patched homolog 1 (PTCH1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
A230106A15Rik antibody, BCNS antibody, FLJ26746 antibody, FLJ42602 antibody, Holoprosencephaly 7 antibody, HPE7 antibody, mes antibody, NBCCS antibody, OTTHUMP00000021709 antibody, OTTHUMP00000021710 antibody, Patched antibody, Patched (Drosophila) homolog antibody, Patched 1 antibody, Patched homolog (Drosophila) antibody, Patched homolog 1 (Drosophila) antibody, Patched homolog 1 antibody, Patched protein homolog 1 antibody, Protein patched homolog 1 antibody, PTC antibody, PTC1 antibody, PTC1_HUMAN antibody, PTCH antibody, PTCH protein +12b antibody, PTCH protein +4' antibody, PTCH protein -10 antibody, PTCH protein antibody, PTCH1 antibody, PTCH1 protein antibody, PTCH11 antibody, Ptch2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Patched recombinant protein (Position: D1219-N1447). Human Patched shares 91% amino acid (aa) sequence identity with mouse Patched.E.coli-derived human Patched recombinant protein (Position: D1219-N1447). Human Patched shares 91% amino acid (aa) sequence identity with mouse Patched.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat.
Predicted to work with: human.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.