PAX3 Polyclonal Antibody

Background:
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells

Synonyms:
PAX3, CDHS, HUP2, WS1, WS3

Immunogen: Recombinant fusion protein of human PAX3 (NP_039230.1).

Swissprot: P23760
Gene ID: 5077

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.