PAX5 antibody (clone 8F9), anti-human
€435.00
In stock
SKU
AC-AT3190a
Catalog Number: AC-AT3190a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, E
Request Information AC-AT3190a">Request Information
Background:
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Other Names:
Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5
Antigen Type:
Recombinant Protein
Gene Name: PAX5
Gene ID: 5079
NCBI Accession: NP_001267476.1;NP_001267477.1;NP_001267478.1;NP_001267479.1;NP_001267481.1;NP_001267482.1;NP_001267483.1;NP_001267484.1;NP_001267485.1;NP_057953.1
Primary Accession: Q02548
Other Accession: NM_016734
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Other Names:
Paired box protein Pax-5, B-cell-specific transcription factor, BSAP, PAX5
Antigen Type:
Recombinant Protein
Gene Name: PAX5
Gene ID: 5079
NCBI Accession: NP_001267476.1;NP_001267477.1;NP_001267478.1;NP_001267479.1;NP_001267481.1;NP_001267482.1;NP_001267483.1;NP_001267484.1;NP_001267485.1;NP_057953.1
Primary Accession: Q02548
Other Accession: NM_016734
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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