PAX5 polyclonal, anti-human, mouse

Background:
The Pax family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. Pax family genes are also involved in a variety of signal transduction pathways in the adult organism. Mutations in Pax proteins have been linked to disease and cancer in humans. For example, the human PAX5 gene encodes a B cell lineage-specific protein, Pax-5, also designated B cell specific activator protein or BSAP, which is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. Pax-5 functions to regulate not only B cell development, but also influences the balance between immunoglobulin secretion and B cell proliferation. Overexpression of Pax-5 has been implicated in cellular transformation, and in the case of small lymphocytic lymphomas with plasmacytoid differentiation, a t(9,14)(p13,q32) translocation resulting in the deregulation of PAX5 gene expression has been detected.

Alternative Name:
BSAP, B cell lineage specific activator, B cell lineage specific activator protein, B cell specific activator protein, B cell specific transcription factor, B-cell-specific transcription factor, BSAP, EBB-1, KLP, Paired box 5, Paired box gene 5 (B cell lineage specific activator protein), Paired box gene 5 (B cell lineage specific activator), Paired box gene 5, Paired box homeotic gene 5, Paired box protein Pax 5, Paired box protein Pax-5, Paired domain gene 5, PAX 5, PAX5, PAX5, Transcription factor PAX 5,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: PAX5 polyclonal antibody detects endogenous levels of PAX5 protein.

Immunogen:
recombinant protein

MW: 42 kDa

Swiss-Prot: Q02548(Human) Q02650(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.