PAX6 polyclonal, anti-human, mouse, rat antibody

Background:
PAX genes encode nuclear transcription factors that may function as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters’ anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.

Other Names:
PAX6 , WAGR , Oculorhombin , AN2 , MGDA , MGC17209 , AN

Primary Accession: P63016

Other Accession: EDL79723

Gene Name: Pax6

Gene ID: 25509

Concentration (mg/ml): 0.5 mg/ml