PAX6 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. In addition, this gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms.

Description:
Rabbit IgG polyclonal antibody for Paired box protein Pax-6 (PAX6) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
AN 2 antibody, AN antibody, AN2 antibody, Aniridia type II protein antibody, D11S812E antibody, FVH1 antibody, MGC17209 antibody, MGDA antibody, Oculorhombin antibody, Paired box 6 antibody, Paired box gene 6 (aniridia keratitis) antibody, Paired Box Gene 6 antibody, Paired box homeotic gene 6 antibody, Paired box protein Pax-6 antibody, Paired box protein Pax6 antibody, PAX 6 antibody, PAX6 antibody, PAX6_HUMAN antibody, Sey antibody, WAGR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human PAX6 (195-233aa EDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTH), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.