PAX7 (Rhabdomyosarcoma Marker) (clone SPM613 ), anti-human

Background:
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).

Other Names:
Paired box protein Pax-7, HuP1, PAX7, HUP1

Gene Name: PAX7
Gene ID: 5081
Primary Accession: P23759
Other Accession: 5081, 113253