PCB polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5841
Background:
Pyruvate carboxylase (PCB) is a biotinylated mitchondrial enzyme that catalyzes the synthesis of oxaloacetate from pyruvate in a tissue specific manner. In addition to covalently binding the biotin cofactor, PCB contains consensus sequences for the attachment of ATP and the substrate pyruvate. The PCB gene is located on the long arm of chromosome 11. Mutations in PCB metabolism (pyruvate carboxylase deficiency) are known to cause lactic acidosis, hypoglycemia and mental retardation.
Alternative Name:
Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: PCB polyclonal antibody detects endogenous levels of PCB protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 400-445 of Human PCB.
MW: ~ 130 kDa
Swis Prot.: P11498
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Pyruvate carboxylase (PCB) is a biotinylated mitchondrial enzyme that catalyzes the synthesis of oxaloacetate from pyruvate in a tissue specific manner. In addition to covalently binding the biotin cofactor, PCB contains consensus sequences for the attachment of ATP and the substrate pyruvate. The PCB gene is located on the long arm of chromosome 11. Mutations in PCB metabolism (pyruvate carboxylase deficiency) are known to cause lactic acidosis, hypoglycemia and mental retardation.
Alternative Name:
Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: PCB polyclonal antibody detects endogenous levels of PCB protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 400-445 of Human PCB.
MW: ~ 130 kDa
Swis Prot.: P11498
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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