PCBP2 Antibody (C-term) Blocking peptide

Background:
The protein encoded by this gene appears to bemultifunctional. Along with PCBP-1 and hnRNPK, it is one of themajor cellular poly(rC)-binding proteins. The encoded proteincontains three K-homologous (KH) domains which may be involved inRNA binding. Together with PCBP-1, this protein also functions as atranslational coactivator of poliovirus RNA via a sequence-specificinteraction with stem-loop IV of the IRES, promoting poliovirus RNAreplication by binding to its 5'-terminal cloverleaf structure. Ithas also been implicated in translational control of the15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, andhepatitis A virus RNA. The encoded protein is also suggested toplay a part in formation of a sequence-specific alpha-globin mRNPcomplex which is associated with alpha-globin mRNA stability. Thismultiexon structural mRNA is thought to be retrotransposed togenerate PCBP-1, an intronless gene with functions similar to thatof PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 andPCBP4) which are thought to have arisen as a result of duplicationevents of entire genes. Thsi gene also has two processedpseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variantsencoding different isoforms have been found for this gene.

Other Names:
Poly(rC)-binding protein 2, Alpha-CP2, Heterogeneous nuclear ribonucleoprotein E2, hnRNP E2, PCBP2

Gene Name: PCBP2 {ECO:0000303|PubMed:7607214, ECO:0000312|HGNC:HGNC:8648}

Gene ID: 5094
Primary Accession: Q15366
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.