PCDHA6 antibody (clone 1A3), anti-human
€435.00
In stock
SKU
AC-AT3220a
Catalog Number: AC-AT3220a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT3220a">Request Information
Background:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Other Names:
Protocadherin alpha-6, PCDH-alpha-6, PCDHA6, CNRS2
Antigen Type:
Recombinant Protein
Gene Name: PCDHA6
Gene ID: 56142
NCBI Accession: NP_061732.1;NP_114036.1;NP_114037.1
Primary Accession: Q9UN73
Other Accession: NM_018909
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Other Names:
Protocadherin alpha-6, PCDH-alpha-6, PCDHA6, CNRS2
Antigen Type:
Recombinant Protein
Gene Name: PCDHA6
Gene ID: 56142
NCBI Accession: NP_061732.1;NP_114036.1;NP_114037.1
Primary Accession: Q9UN73
Other Accession: NM_018909
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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