PCDHGA1 polyclonal (Center), anti-human
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In stock
SKU
AC-AP11662C
Catalog Number: AC-AP11662C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB31763
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB31763
Applications: IHC-P, WB
Datasheet
Request Information
Background:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Other Names:
Protocadherin gamma-A1, PCDH-gamma-A1, PCDHGA1
Target/Specificity:
This PCDHGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the Central region of human PCDHGA1.
Antigen Region:
287-315
Antigen Type: Synthetic Peptide
Gene Name: PCDHGA1
Gene ID: 56114
Primary Accession: Q9Y5H4
NCBI Accession: NP_061735.1;NP_114382.1
Other Accession: NP_061735.1;NP_114382.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Other Names:
Protocadherin gamma-A1, PCDH-gamma-A1, PCDHGA1
Target/Specificity:
This PCDHGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the Central region of human PCDHGA1.
Antigen Region:
287-315
Antigen Type: Synthetic Peptide
Gene Name: PCDHGA1
Gene ID: 56114
Primary Accession: Q9Y5H4
NCBI Accession: NP_061735.1;NP_114382.1
Other Accession: NP_061735.1;NP_114382.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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